منابع مشابه
Unconsciousness associated with midazolam and erythromycin.
An 8-yr-old boy suffering from an asymptomatic ventricular septal defect was given erythromycin for antibiotic prophylaxis before adenoidectomy. Sixty minutes after premedication with oral midazolam 0.5 mg kg-1 and oral atropine 0.03 mg kg-1, an infusion of erythromycin 400 mg was started. When 200 mg of erythromycin had been infused, the patient lost consciousness, but other vital functions re...
متن کاملThe erythromycin breath test predicts the clearance of midazolam.
Midazolam, a commonly used sedative and amnestic medication, has recently been shown to be largely metabolized in the liver by a cytochrome P450, termed CYP3A4. There is at least a tenfold intersubject variability in the liver content and catalytic activity of CYP3A4, which may in part account for the known interpatient differences in the kinetics of midazolam. To test this hypothesis, we deter...
متن کاملProlonged sedation related to erythromycin and midazolam interaction: a word of caution.
A 6 year old, 24 kg boy was referred for do an outpatient magnetic resonance imaging of the pelvis and femur as he was suffering with fever and progressive pain in hip area and limping. The boy was otherwise healthy, with an unremarkable medical history and review of systems. He was taking some medicines for fever, and the details were not known. As he was having a fear of injection, oral midaz...
متن کاملPreparation and evaluation of a new erythromycin derivative -- erythromycin taurate.
Erythromycin taurate, a new derivative of erythromycin, was prepared by reacting erythromycin base with tauric acid and its physico-chemical and biological properties were evaluated. The derivative has reasonably good solubility in organic solvents. The partition coefficient values in chloroform/water 1.17 and octanol/water 1.16 systems indicate its good distribution in various tissues in vivo....
متن کاملErythromycin and the gut.
The commonly reported gastrointestinal side effects that occur with erythromycin are related to its prokinetic action on the gut, mediated, at least in part, by its motilin receptor stimulating activity. This action may be of clinical use in conditions associated with gastrointestinal hypomotility such as diabetic gastroparesis and intestinal pseudo-obstruction, although further work needs to b...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1991
ISSN: 0007-0912
DOI: 10.1093/bja/67.1.131-a